- No. 1 Victoria Azarenka vs. No. 7 Samantha Stosur
- No. 3 Maria Sharapova vs. No. 11 Marion Bartoli
- No. 4 Serena Williams vs. No. 12 Ana Ivanovic
- No. 10 Sara Errani vs. No. 20 Roberta Vinci
No. 7 Samantha Stosur is the defending champion. No. 3 Maria Sharapova is the 2006 champion and No. 4 Serena Williams is the 1999, 2002 and 2008 champion.
For Errani and Vinci, it will be an all-Italian quarterfinals between the second-seeded doubles partners from Italy.